(as of Jul 16,2020 15:22:42 UTC – Details)
In 1981, the Life Extension Foundation introduced DHEA (dehydroepiandrosterone) to its members through an article that described the multiple benefits this hormone might produce. However, the general public did not learn about DHEA until 1996, when its benefits were touted by the news media and in several popular books. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book presented scientific validation of many life-extending effects of DHEA.
It has been shown that the serum hormone DHEA often declines by 75%–80% from peak levels by age 70, leading to hormonal imbalances that can affect one’s quality of life.1-4 Peak blood levels of DHEA occur at approximately age 25, decreasing progressively thereafter.3 The marked decline in serum DHEA with age is believed to play a role in health problems associated with aging. Thus, scientists have been looking at ways of restoring DHEA to youthful levels to prevent or reverse those health issues, and are now discovering mechanisms by which DHEA protects against age-related decline.
Since 1981, several thousand studies have been published on DHEA’s various benefits, including immunomodulatory properties as well as positive effects on mood, quality of life, and body composition. It has been proposed that restoring the circulating levels of DHEA to those found in young people may improve well-being and sexual function. In a randomized, double-blind, placebo-controlled study, ten months of DHEA replacement therapy showed a beneficial effect of enhancing the increases in muscle mass and strength with the addition of resistance exercise in elderly individuals.4 The studies of DHEA therapy in women with adrenal insufficiency also suggest beneficial effects on well-being, mood, and sexuality.5 DHEA could be of benefit to the normal aging brain.6-8 Some studies have reported DHEA may improve mood and alleviate melancholy.9